Research
研究
界面活性剤や脂質、高分子やタンパク質等は、水中で様々な凝集構造を形成します。界面活性剤が作るミセルは有名ですが、それ以外にも膜やタンパク質の折り畳み構造など、様々な構造を自己組織的に形成します。この自己組織化構造は、その物質の物性や機能に密接に関わっています。たとえば、リン脂質が形成する二重膜は生体膜の基本構造として有名ですが、その膜構造の変化が生体膜の機能に関わっていることが知られています。また、化粧品や塗料、食品、そして生体分子などの性質や機能にも、自己組織化構造が深く関与しています。
我々は、こういった様々な自己組織化構造が形成されるメカニズムを物理化学的に理解することを目指しています。このメカニズムが生命現象や工業製品の機能にどう関わるのかにもアプローチしています。さらに、そこに「水」がどう関与しているかにも注目しています(生命に水はなぜ重要か?)。まさに、化学と物理、生物学の中間の領域で、分野の壁を飛び越えながら多角的に研究を進めています。
X線や中性子による構造解析、熱測定、各種分光法、各種顕微鏡観察、表面張力測定など多種多様な手法を使い分けながら現象に迫るのも本研究室の特徴です。理論の構築にチャレンジすることもあります。複数の視点から俯瞰的に現象を眺めることが、世界初の発見につながると考えています。X線や中性子を用いた実験は外部の大型施設(放射光施設)に出張して行っています。また、多くの大学・研究所・企業とも共同研究を進めています。
Surfactants, lipids, polymers, and proteins form various aggregate structures in water. Micelles created by surfactants are well-known, but other structures such as membranes and protein folding structure can also be formed in a self-assembled manner. These self-assembled structures are closely related to the physical properties and functions of these materials. For example, the bilayer membrane formed by phospholipids is well known as the basic structure of biomembranes, and it is known that changes in the membrane structure are related to the function of biomembranes. Self-assembling structures are also deeply involved in the properties and functions of cosmetics, paints, foods, and biomolecules.
Our goal is to understand the formation mechanism of these various self-assembled structures from a physicochemical viewpoint. We are also approaching how this mechanism relates to biological phenomena and functions of industrial materials. Furthermore, we are also focusing on how “water” is involved in this process. (We want to know why water is important for life.) This is truly an area between chemistry, physics, and biology, and we are conducting research from multiple perspectives while jumping across disciplinary boundaries.
Another characteristic of our laboratory is that we approach phenomena by using a wide variety of methods, such as structural analysis using X-rays and neutrons, thermal measurement, various spectroscopic methods, various microscopic observations, and surface tension measurement. We also take on the challenge of constructing theories. Experiments using X-rays and neutrons are conducted at large external facilities (synchrotron radiation facilities). We are also conducting joint research with many other universities, research institutes, and companies.
代表的な研究テーマ
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高分子の温度応答性に水和水がどう関わっているのか?
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タンパク質の構造安定性や機能に水和水がどのように関与しているのか?
Research Topics
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How is hydration water related to the thermo-responsive property of polymers?
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How is hydration water involved in the structural stability and function of proteins?
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The origin of the phase transition between interdigitated and bilayer membrane of ionic surfactant
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Elucidation of the formation mechanism of phospholipid giant vesicles.